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KMID : 0880520190550030127
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Chonnam Medical Journal
2019 Volume.55 No. 3 p.127 ~ p.135
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Identification of Radioactive Iodine Refractory Differentiated Thyroid Cancer
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Mu Zhuan-Zhuan
Zhang Xin
Lin Yan-Song
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Abstract
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Most differentiated thyroid cancer (DTC) patients have an excellent prognosis. However, about one-third of DTC patients with recurrent or metastatic disease lose the hallmark of specific iodine uptake initially or gradually and acquire radioactive iodine-refractory DTC (RAIR-DTC) with poor prognosis. Due to the potentially severe complications from unnecessarily repeated RAI therapy and encouraging progress of multiple targeted drugs for advanced RAIR-DTC patients, it has become crucial to identify RAIR-DTC early. In this review, we focus on the progress and controversies regarding the defining of RAIR-DTC, further with subsistent approaches and promising molecular nuclear medicine imaging in identifying RAIR-DTC, which may shed light on the proper management methodsof such patients.
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KEYWORD
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Thyroid Neoplasms, Iodine Radioisotopes, Molecular Imaging
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